Introduction to Downstream Processing

Due to the realistic production environment of our state-of-the-art facility, we are able to offer this unique training, which focuses not only on theory but also on the practice of manufacturing biopharmaceutical products.

1 day
Course fee
€ 995 (excl. VAT)

Short description

What can you expect from this Downstream Processing training course?

Average score from participants of the previous course: 9!

This course provides all background information needed to fully understand the purification process of downstream processing. The theory section explains the basis of various aspects that are essential to produce biopharmaceutical products in a GMP environment. 

The practical part takes place in a real production environment, allowing the participants to experience the importance of working in a cleanroom. Various techniques are performed either by the participants themselves, or demonstrated by an experienced operator.

The course consists of 2 modules which can also be followed separately:

Module 1: Introduction to Upstream Processing (1 day). For more information click here

Module 2: Introduction to Downstream Processing (1 day).


After the training sessions, the participants have knowledge of:

  • the different process steps that are important for the purification of (bio)pharmaceutical products
  • basic principles of various purification techniques for use in downstream processing, including chromatography, ultrafiltration, diafiltration and centrifugation.
  • various virus elimination and inactivation techniques
  • the operation of sealing and welding equipment

Target group

Who should follow this Downstream Course?

Anyone who wants to know more about the production of biotechnological pharmaceutical products. These may include for instance production operators, QA and auditors.

This course is also intended for QC analysts and validation staff who want to increase their pharmaceutical knowledge in the field of biotechnological products.


Day 1



Production process - pollution profile
Virus inactivation and virus removal
Various downstream processing techniques, including:
• Chromatography
• Clarification (e. g. with filters)
• Ultrafiltration/diafiltration (UF/DF)
• Formulation
• In process controls (IPC)
Critical aspects during production



Welding; the use of welding devices
DSP in practice:
• Sampling techniques
• Clarification
• Chromatography
• Ultrafiltration/diafiltration

The above techniques are carried out in a practical, real-life environment, where certain aspects are performed by the participants themselves and other aspects are shown and explained in a demonstration.



Sign up

Interested in signing up a group of people for this course?

Please contact our Business Development team:
+31 (0)88 2830100

Know how.
Know why.

Need help? Have a question or a suggestion maybe?

Drop us a line below or call us on
+31 (0) 88 283 01 00.